Figure 2
Conceptual drawing of the human PrP molecule
The following features are illustrated:
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Color-coded regional conformations (pink sections are unstructured, orange sections are alpha helical domains, and rectangular sections are anti-parallel beta sheets);
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Locations of an 8-octapeptide repeat region near the N-terminus, and of two asparagine-linked carbohydrates and a single disulfide bond near the C-terminus;
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Post-translational replacement of twenty C-terminus amino acid residues (at position 232) by a glycosyl-phosphatidyl-inositol (GPI) cell membrane anchor;
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Sites and identities of pathogenic point mutations (yellow, with unidirectional arrows) and polymorphisms (blue, with bi-directional arrows); a polymorphic octapeptide deletion and multiple pathogenic octapeptide insert mutations are also indicated.
